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    <loc>https://www.pain-science.org/about</loc>
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    <lastmod>2023-04-04</lastmod>
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      <image:title>About - Founder &amp; Director</image:title>
      <image:caption>Dr. John Markman directs the Translational Pain Research Program in the Department of Neurosurgery and is a Professor at the University of Rochester School of Medicine and Dentistry. Dr. Markman leads the Department of Neurosurgery's Neuromedicine Pain Management Center, a multi-specialty pain practice with a focus on patients with chronic pain associated with nerve injury. His practice and center offerings includes the gamut of medical, interventional, and behavioral therapies for chronic pain. His clinical research on chronic pain and low back pain have recently appeared in Journal of Pain, Pain, Clinical Pharmacology and Therapeutics, Rheumatology, Neurology, Anesthesiology Clinics of North America, Medical Clinics of North America, and Geriatric Clinics of North America in addition to numerous book chapters and non peer-reviewed publications.</image:caption>
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      <image:title>About</image:title>
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      <image:title>About</image:title>
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      <image:title>About</image:title>
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      <image:title>About</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e443653e9d64d13b2ec7de0/1604517596030-WBNXC1A48YUH2M8LQC8M/placeholder.png</image:loc>
      <image:title>About</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e443653e9d64d13b2ec7de0/1604517596030-WBNXC1A48YUH2M8LQC8M/placeholder.png</image:loc>
      <image:title>About</image:title>
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      <image:title>About</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/chronic-low-back-pain-syndromes</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-04-15</lastmod>
  </url>
  <url>
    <loc>https://www.pain-science.org/contact-us</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-07-31</lastmod>
  </url>
  <url>
    <loc>https://www.pain-science.org/core-antibody-therapy</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
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      <image:title>Core_Antibody Therapy - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
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      <image:title>Core_Antibody Therapy</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Antibody Therapy</image:title>
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      <image:title>Core_Antibody Therapy</image:title>
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      <image:title>Core_Antibody Therapy</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Antibody Therapy</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Antibody Therapy</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-chronic-low-back-pain</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
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      <image:title>Core_Chronic Low Back Pain - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
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      <image:title>Core_Chronic Low Back Pain</image:title>
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      <image:title>Core_Chronic Low Back Pain</image:title>
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    <image:image>
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      <image:title>Core_Chronic Low Back Pain</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Low Back Pain</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Low Back Pain</image:title>
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      <image:title>Core_Chronic Low Back Pain</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-chronic-neuropathic-pain-syndromes</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
    <image:image>
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      <image:title>Core_Chronic Neuropathic Pain Syndromes - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
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    <image:image>
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      <image:title>Core_Chronic Neuropathic Pain Syndromes</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-clinical-trial-design</loc>
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    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
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      <image:title>Core_Clinical Trial Design - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Clinical Trial Design</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-innovative-pain-assessment</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e443653e9d64d13b2ec7de0/1595014772567-SN68Q3IXXWYN8SWD097S/imotions+picture.png</image:loc>
      <image:title>Core_Innovative Pain Assessment - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
    </image:image>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Innovative Pain Assessment</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-neuromodulation</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5e443653e9d64d13b2ec7de0/1590163450715-CLQA7S1KOXSJHDHHB61P/Research_spinal%2Bcord%2Bstimulator.jpg</image:loc>
      <image:title>Core_Neuromodulation - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810059-DD42TW118D0HPYA5VMXV/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
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    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Neuromodulation</image:title>
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  </url>
  <url>
    <loc>https://www.pain-science.org/core-novel-analgesic-study-endpoints</loc>
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    <priority>0.75</priority>
    <lastmod>2020-08-03</lastmod>
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      <image:loc>https://images.squarespace-cdn.com/content/v1/5e443653e9d64d13b2ec7de0/1594994060185-9XRDO760KQX8NHHV3MNC/Actigraph.png</image:loc>
      <image:title>Core_Novel Analgesic Study Endpoints - Make it stand out.</image:title>
      <image:caption>It all begins with an idea. Maybe you want to launch a business. Maybe you want to turn a hobby into something more. Or maybe you have a creative project to share with the world. Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810298-OE2TCASTBRN32929CY0H/image-asset.jpeg</image:loc>
      <image:title>Core_Novel Analgesic Study Endpoints</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1589847810532-JII23ESHYQCQ1ADQIKPQ/image-asset.jpeg</image:loc>
      <image:title>Core_Novel Analgesic Study Endpoints</image:title>
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      <image:caption>Gewandter will Deliver Lecture at 39th IASP World Conference in Seville, Spain Our Pain Science member, Jennifer Gewandter, PhD, MPH, will deliver a lecture in this year’s IASP World Conference in Seville, Spain! The virtual webinar event times are to be announced. From 27-30 September 2022, Cartuja Science and Technology Park will host the IASP World Conference. The theme this year is ‘Green and digital change powered by innovation: The role of innovation ecosystems’. Date: 9/27/2022 - 9/30/2022 | Time: TBA | Location: IASP Virtual Webinar</image:caption>
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      <image:caption>April 22, 2023 John Markman, M.D., delivers a lecture on the ‘Advances in Pain Neurology 2023 Recalibrating the Benefit/Risk Tradeoffs for Pain Relievers’ in the American Academy of Neurology Conference in Boston, MA. American Academy of Neurology 2023 Annual Meeting | Boston, MA</image:caption>
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      <image:caption>May 10, 2023 John Markman, M.D., delivers a lecture on the ‘Questions and Lessons About Placebo Effect Gleaned from Contemporary Analgesic Clinical Trials’ in the Canadian Pain Society Annual Meeting 2023 in Banff, Canada. Canadian Pain Society Annual Meeting 2023 | Banff, Canada</image:caption>
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      <image:title>Education_Conferences - Contemporary debates in neuromodulation: Screening Trials in Patients with Chronic Neuropathic Pain</image:title>
      <image:caption>January 12, 2023 John Markman, M.D., delivers a lecture on the ‘Advances in Pain Neurology 2023 Recalibrating the Benefit/Risk Tradeoffs for Pain Relievers’ in the American Academy of Neurology Conference in Boston, MA. North American Modulation Society Meeting 2023 | Las Vegas, NV</image:caption>
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      <image:caption>Ahab’s gift: Herman Melville’s Moby Dick and the meaning of pain In the summer months before my first year of medical school, I unfurled the pages of Moby Dick. Immersed in the novel’s adventurous spirit and Shakespearean prose, I followed the narrator from the piers of Nantucket into the Atlantic and waded through Captain Ahab’s quest for the legendary white whale. I was ostensibly reading for fun—but in truth, what got me to read Melville’s classic was a rising and distressing awareness of the stage upon which I was about to walk. My future career in medicine loomed large in my mind, and I knew that the time for reading literary fiction was about to disappear…</image:caption>
    </image:image>
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  <url>
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      <image:caption>Developing more effective and safer pain treatments for patients everywhere.</image:caption>
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      <image:caption>Sharing the evidence that will foster a cultural transformation in our understanding of pain.</image:caption>
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      <image:caption>Bringing understanding and compassion to each person’s search for relief.</image:caption>
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      <image:caption>The Translational Pain Research Program is a specialized clinical research organization.</image:caption>
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      <image:title>Markman Recognized for Contributions to Pain Research</image:title>
      <image:caption>March 14, 2022 John Markman, M.D., has been named the 2022 Mitchell Max Scientific Award recipient for his contributions to pain research by the American Academy of Neurology (AAN). Markman is a professor of Neurosurgery and Neurology director of the Translational Pain Research Program, and chief of the Division of Pain Medicine.</image:caption>
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      <image:title>Advances in Pain Neurology 2023 Recalibrating the Benefit/Risk Tradeoffs for Pain Relievers</image:title>
      <image:caption>April 22, 2023 John Markman, M.D., delivers a lecture on the ‘Advances in Pain Neurology 2023 Recalibrating the Benefit/Risk Tradeoffs for Pain Relievers’ in the American Academy of Neurology Conference in Boston, MA.</image:caption>
    </image:image>
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      <image:title>Research_Book Chapters - The Netter Collection of Medical Illustrations: Nervous System, Part II</image:title>
      <image:caption>Description The Netter Collection of Medical Illustrations: Nervous System, 2nd Edition provides a highly visual guide to the brain, spinal cord, and peripheral motor and sensory systems. These two spectacularly illustrated volumes in the masterwork known as the (CIBA) Netter "Green Books" have been expanded and revised by Drs. H. Royden Jones, Jr., Ted M. Burns, Michael J. Aminoff, and Scott L. Pomeroy to mirror the many exciting advances in medicine and imaging - offering rich insights into neuroanatomy, neurophysiology, and the broad clinical spectrum of neurological diseases and disorders. Authors: H. Royden Jones, Ted M. Burns, Michael J. Aminoff, and Scott L. Pomeroy</image:caption>
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      <image:caption>Description Written by internationally renowned leaders in the fields of peripheral neuropathy and neuropathic pain, this resource discusses the clinical approaches to diagnosis and treatment of neuropathic pain, its underlying mechanisms, and strategies for prevention. In addition, chapters cover timely issues, including legal and ethical concerns surrounding pain treatment, the status of clinical trial methods, and educational efforts. Comprehensive yet concise, it serves as a guide for diagnostic approaches and treatment of neuropathic pain. Authors: David M. Simpson, Justin C. McArthur, and Robert H. Dworkin</image:caption>
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      <image:caption>Description Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry. Authors: Bernard Ravina, Jeffrey Cummings, Michael McDermott, and R. Michael Poole</image:caption>
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      <image:title>Research_Lay Press</image:title>
      <image:caption>SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back (2019)</image:caption>
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      <image:caption>Efficacy of pregabalin in post-traumatic peripheral neuropathic pain: a randomized, double-blind, placebo-controlled phase 3 trial (2018)</image:caption>
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      <image:caption>Differences in opioid prescribing in low back pain patients with and without depression (2017)</image:caption>
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      <image:caption>Double-blind, randomized, controlled, crossover trial of pregabalin for neurogenic claudication (2015)</image:caption>
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  </url>
  <url>
    <loc>https://www.pain-science.org/treatment</loc>
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    <priority>0.75</priority>
    <lastmod>2020-08-21</lastmod>
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    <image:image>
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      <image:title>Treatment</image:title>
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    <image:image>
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    <image:image>
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      <image:caption>Dr. Armando Villarreal</image:caption>
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  </url>
</urlset>

